2-[4-(4-fluorobenzyl)piperazin-1-yl]ethanol

2-[4-(4-fluorobenzyl)piperazin-1-yl]ethanol - Names and Identifiers

Name	1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine
Synonyms	2-[4-(4-FLUOROBENZYL)PIPERAZINO]ETHAN-1-OL 2-(4-(4-Fluorobenzyl)piperazin-1-yl)ethanol 2-[4-(4-fluorobenzyl)piperazin-1-yl]ethanol 1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine 1-(4-FLUOROBENZYL)-4-(2-HYDROXYETHYL)PIPERAZINE 1-Piperazineethanol, 4-[(4-fluorophenyl)methyl]- 2-[4-[(4-fluorophenyl)methyl]-1-piperazinyl]ethanol
CAS	174561-11-6
InChI	InChI=1/C13H19FN2O/c14-13-3-1-12(2-4-13)11-16-7-5-15(6-8-16)9-10-17/h1-4,17H,5-11H2

2-[4-(4-fluorobenzyl)piperazin-1-yl]ethanol - Physico-chemical Properties

Molecular Formula	C13H19FN2O
Molar Mass	238.3
Density	1.155g/cm³
Melting Point	55 °C
Boling Point	356°C at 760 mmHg
Flash Point	169.1°C
Vapor Presure	1.1E-05mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	1.549
MDL	MFCD00203973

2-[4-(4-fluorobenzyl)piperazin-1-yl]ethanol - Risk and Safety

Risk Codes	22 - Harmful if swallowed
Hazard Note	Irritant

2-[4-(4-fluorobenzyl)piperazin-1-yl]ethanol - Introduction

1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine is an organic compound with the chemical formula C12H16FN3O. Its Properties, Uses, preparation methods and safety information are as follows:

Nature:
1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine is a white solid with a molecular weight of 253.27g/mol. It has strong solubility at room temperature and can be dissolved in water and some organic solvents.

Use:
1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine has a wide range of applications in the field of medicine. It is used as an intermediate for angiotensin II receptor blockers and can be used to make treatments for high blood pressure and heart disease. In addition, it can also be used as an intermediate for other drugs, such as antidepressants, anxiolytics, etc.

Method:
The preparation of 1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine can be carried out by a multistep reaction. First, a Hydroxyethyl group is introduced on the benzene ring by an etherification reaction. Subsequently, a fluorine atom is introduced into the benzyl group by a fluorination reaction. Finally, an amino group is introduced on The piperazine ring by a condensation reaction. Thus the final product is obtained.

Safety Information:
Under correct handling and storage conditions, 1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine is generally relatively safe. But as a chemical, it may be toxic to the human body. In the use of the process should pay attention to comply with the safety procedures, to avoid inhalation, intake or contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water and seek medical assistance if necessary.

Last Update：2024-04-09 21:01:54